Comparing sprint and endurance training on anxiety, depression and its relation with brain-derived neurotrophic factor in rats

TaheriChadorneshin, Hossein and Cheragh-Birjandi, Sadegh and Ramezani, Saeed and Abtahi-Eivary, Seyed-Hosein (2017) Comparing sprint and endurance training on anxiety, depression and its relation with brain-derived neurotrophic factor in rats. Behavioural Brain Research, 329. 1 - 5.

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Abstract

Abstract Although the response of brain-derived neurotrophic factor (BDNF) has been shown to low intensity exercise training, but the effect of intensive exercise training is not clear. Also, there is insufficient information about relationship between {BDNF} and depression and anxiety following intensive exercise. This study aimed to investigate the effects of 6 weeks of intensive endurance training (ET) and sprint interval training (SIT) on brain {BDNF} and its relationship with anxiety and depression in Albino Wistar rats. Anxiety and depression of rats were measured by elevated plus maze (EPM) and tail suspension test (TST), respectively. All data were analyzed using one-way {ANOVA} and Pearson’s correlation coefficient at P < 0.05 level. Both {SIT} and {ET} regimens increased {BDNF} content in the brain, and the alterations made were greater following {SIT} than ET. Also, both {SIT} and {ET} regimens increased number of entries and the time spent in the open arm significantly in EPM, with a higher elevation following {SIT} than ET. In addition, both {SIT} and {ET} regimens decreased number and duration of immobility significantly in TST, with a higher reduction following {SIT} than ET. Furthermore, {BDNF} content correlated positively with number of entries and the time spent in the open arm in {EPM} and negatively with number and duration of immobility in TST. Collectively, sprint interval training regimen, rather than intensive endurance training regimen, is highly potential to improve anxiety and depression through a greater increase in {BDNF} contents in brain.

Item Type: Article
Uncontrolled Keywords: Tail suspension test
Subjects: R Medicine > R Medicine (General)
Depositing User: Unnamed user with email eprints@gmu.ac.ir
Date Deposited: 08 May 2017 05:25
Last Modified: 08 May 2017 05:25
URI: http://eprints.gmu.ac.ir/id/eprint/169

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