Relationship between serum cytokines receptors and matrix metalloproteinase 9 levels and coronary artery disease

Mirhafez, Seyed Reza and Avan, Amir and Tajfard, Mohammad and Mohammadi, Shabnam and Moohebati, Mohsen and Fallah, Arash and Ghazavi, Hamed and Savadi, Hossein and Ghayour Mobarhan, Majid (2016) Relationship between serum cytokines receptors and matrix metalloproteinase 9 levels and coronary artery disease. Journal of Clinical Laboratory Analysis.

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Background The prevalence of coronary artery disease (CAD) is increasing globally, supporting the need for the identification of novel biomarkers. Therefore in the present study, we have explored the association of SIL2A, SIL6R, STNFRI, STNFRII, and MMP9 in CAD patients. Methods Twenty one patients with angiographically defined CAD with more than 50% occlusion, at least, in one coronary artery and twenty healthy subjects (n=20) without the history of cardiovascular symptoms were enrolled. Demographic and biochemical analysis (e.g. Total Cholesterol (TC), Triglyceride (TG), and HDL-C) were measured in all the subjects. The level of cytokines receptor (SIL2A, SIL6R, SIL6R, STNFRI, STNFRII, and matrix metallopeptidase 9 (MMP9) were evaluated. Results Our results showed the higher level of MMP9 in patients group compared to the control subjects, while no significant differences were detected for other cytokines. In particular the level of MMP9 was significantly (P=.015) increased from 181.16 ng/mL (95%CI: 112.1-199.2) to 192.0 ng/mL (95%CI: 181.5-265.2). Moreover, the sensitivity and specificity of MMP9 were 95.45% and 45%, respectively, as detected by receiver operating characteristic (ROC) curves. Conclusion We demonstrate the significant correlation of MMP-9 with CAD with sensitivity of 95.45%, suggesting its role as a biomarker in CAD patients. Further studies in larger population – preferably multicenter setting – are warranted to explore the functional role of this marker in coronary artery disease.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Depositing User: Unnamed user with email
Date Deposited: 10 May 2017 04:58
Last Modified: 10 May 2017 04:58

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