Mesenchymal stromal cells; a new horizon in regenerative medicine

Tavakoli, Shirin and Ghaderi Jafarbeigloo, Hamid Reza and Shariati, Ali and Jahangiryan, Afsaneh and Jadidi, Faezeh and Jadidi Kouhbanani, Mohammd Amin and Hassanzadeh, Ali and Zamani, Majid and Javidi, Kamran and Naimi, Adel Mesenchymal stromal cells; a new horizon in regenerative medicine. Journal of Cellular Physiology, n/a (n/a).

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Official URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/jc...

Abstract

Abstract In recent decades, mesenchymal stromal cells (MSCs) biomedical utilizing has attracted worldwide growing attention. After the first report of the human MSCs obtaining from the bone marrow (BM) tissue, these cells were isolated from wide types of the other tissues, ranging from adipose tissue to dental pulp. Their specific characteristics, comprising self-renewality, multipotency, and availability accompanied by their immunomodulatory properties and little ethical concern denote their importance in the context of regenerative medicine. Considering preclinical studies, MSCs can modify immune reactions during tissue repair and restoration, providing suitable milieu for tissue recovery; on the other hand, they can be differentiated into comprehensive types of the body cells, such as osteoblast, chondrocyte, hepatocyte, cardiomyocyte, fibroblast, and neural cells. Though a large number of studies have investigated MSCs capacities in regenerative medicine in varied animal models, the oncogenic capability of unregulated MSCs differentiation must be more assessed to enable their application in the clinic. In the current review, we provide a brief overview of MSCs sources, isolation, and expansion as well as immunomodulatory activities. More important, we try to collect and discuss recent preclinical and clinical research and evaluate current challenges in the context of the MSC-based cell therapy for regenerative medicine.

Item Type: Article
Uncontrolled Keywords: cell therapy, differentiation, mesenchymal stromal cells (MSCs), regenerative medicine, sources
Subjects: R Medicine > RZ Other systems of medicine
Depositing User: Unnamed user with email eprints@gmu.ac.ir
Date Deposited: 26 Sep 2020 10:00
Last Modified: 26 Sep 2020 10:00
URI: http://eprints.gmu.ac.ir/id/eprint/1872

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