HepatoprotectiveEffects of Combination Hydroalcoholic Extracts of Nigella Sativa and Curcuma Longa on Adriamycin-Induced Oxidative Stress in Rat

Mohebbatia, Reza and Khazdair, Mohammad Reza and Karimia, Sareh and Abbasnezhadd, Abbasali (2017) HepatoprotectiveEffects of Combination Hydroalcoholic Extracts of Nigella Sativa and Curcuma Longa on Adriamycin-Induced Oxidative Stress in Rat. Journal of Reports in Pharmaceutical Sciences, 6 (2). pp. 93-102.

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Abstract

The ample of studies show that Adriamycin caused hepatotoxicity in rat. The present study investigated the effects of Nigella Sativa (N. Sativa) and combination with Curcuma longa (C. longa) extract on Adriamycin-induced hepatotoxicity in rat. Rats were divided into eight experimental groups: Control (CO), Adriamycin (ADR), Vitamin C (Vit C), Adriamycin with Vitamin C (ADR+VitC), N. Sativa with and without Adriamycin (NS +ADR, NS -ADR), Combination extract of C. longa and N. Sativa with and without Adriamycin (NS+CL+ADR, NS+CL-ADR). Malondialdehyde (MDA) and thiol levels and also the activities of catalase (CAT) in liver tissue were evaluated. MDA level in the liver tissue in ADR was increased compared to CO group but in NS+ADR group, ADR+VitC and NS –ADR groups decreased compared to ADR group. Thiol levels in ADR and ADR+VitC groups were decreased compared to CO group. Thiol levels in treatment groups were increased compared to ADR group. The activities of CAT in liver tissue of ADR group were lower than CO group, and increased in treatment groups comparison with ADR group. The results showed that chronic administration of N. sativa hydroalcoholic extract in Adriamycin-induced hepatotoxicity rats could decrease the oxidative stress injuries in liver tissue.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
R Medicine > RZ Other systems of medicine
Depositing User: Unnamed user with email eprints@gmu.ac.ir
Date Deposited: 17 Sep 2017 07:44
Last Modified: 17 Sep 2017 07:44
URI: http://eprints.gmu.ac.ir/id/eprint/238

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