Effects of curcumin on NF-κB, AP-1, and Wnt/β-catenin signaling pathway in hepatitis B virus infection

Hesari, AmirReza and Ghasemi, Faezeh and Salarinia, Reza and Biglari, Hamed and Tabar Molla Hassan, Agheel and Abdoli, Vali and Mirzaei, Hamed (2018) Effects of curcumin on NF-κB, AP-1, and Wnt/β-catenin signaling pathway in hepatitis B virus infection. Journal of Cellular Biochemistry. ISSN 07302312

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Official URL: http://doi.org/10.1002/jcb.26829

Abstract

Curcumin is a yellow‐orange powder derived from the Curcuma longa plant. Curcumin has been used extensively in traditional medicine for centuries. This component is non‐toxic and shown different therapeutic properties such as anti‐inflammatory, anti‐cancer, antiviral, anti‐bacterial, anti‐fungal, anti‐parasites, and anti‐oxidant. Hepatitis B virus (HBV) is a small DNA member of the genus Orthohepadnavirus (Hepadnaviridae family) which is a highly contagious blood‐borne viral pathogen. HBV infection is a major public health problem with 2 billion people infected throughout the world and 350 million suffering from chronic HBV infection. Increasing evidence indicated that curcumin as a natural product could be employed in the treatment of HBV patients. It has been showed that curcumin exerts its therapeutic effects on HBV patients via targeting a variety of cellular and molecular pathways such as Wnt/β‐catenin, Ap1, STAT3, MAPK, and NF‐κB signaling. Here, we summarized the therapeutic effects of curcumin on patients who infected with HBV. Moreover, we highlighted main signaling pathways (eg, NF‐κB, AP1, and Wnt/β‐catenin signaling) which affected by curcumin in HBV infections.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Depositing User: Unnamed user with email eprints@gmu.ac.ir
Date Deposited: 03 Jul 2018 10:03
Last Modified: 03 Jul 2018 10:03
URI: http://eprints.gmu.ac.ir/id/eprint/406

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