Micro-RNAs as critical regulators of matrix metalloproteinases in cancer

Noruzi, Somaye and Azizian, Mitra and Mohammadi, Rezvan and Hosseini, Seyede Atefe and Rashidi, Bahman and Mohamadi, Yousef and Nesaei, Abolfazl and Seiri, Parvaneh and Sahebkar, Amirhossein and Salarinia, Reza and Aghdam, Arad Mobasher and Mirzaei, Hamed Micro-RNAs as critical regulators of matrix metalloproteinases in cancer. Journal of Cellular Biochemistry.

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Official URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/jc...

Abstract

Abstract Metastasis is known to be one of the important factors associated with cancer-related deaths worldwide. Several cellular and molecular targets are involved in the metastasis process. Among these targets, matrix metalloproteinases (MMPs) play central roles in promoting cancer metastasis. MMPs could contribute toward tumor growth, angiogenesis, migration, and invasion via degradation of the extracellular matrix and activation of pre-pro–growth factors. Therefore, identification of various cellular and molecular pathways that affect MMPs could contribute toward a better understanding of the metastatic pathways involved in various tumors. Micro-RNAs are important targets that could affect MMPs. Multiple lines of evidence have indicated that deregulation of various micro-RNAs, including miR-9, Let-7, miR-10b, and miR-15b, affects metastasis of tumor cells via targeting MMPs.

Item Type: Article
Uncontrolled Keywords: cancer, matrix metalloproteinases, metastasis, micro-RNAs
Subjects: R Medicine > RZ Other systems of medicine
Depositing User: Unnamed user with email eprints@gmu.ac.ir
Date Deposited: 02 Oct 2018 04:26
Last Modified: 02 Oct 2018 04:26
URI: http://eprints.gmu.ac.ir/id/eprint/443

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