Optimization of PLGA formulation containing protein or peptide-based antigen: Recent advances

Hajavi, Jafar and Ebrahimian, Mahboubeh and Sankian, Mojtaba and Khakzad, Mohammad Reza and Hashemi, Maryam Optimization of PLGA formulation containing protein or peptide-based antigen: Recent advances. Journal of Biomedical Materials Research Part A, 106 (9). pp. 2540-2551.

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Official URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/jb...


Abstract Protein or peptide-based antigens are the most promising forms to generate custom protective immune responses for clinical applications. Over the last decades, poly(lactic-co-glycolic acid) (PLGA) as a biodegradable polymer has gained more attention for delivery of protein and peptide. Besides many appropriate characteristics, to improve its properties to overcome some obstacles such as release profile and it is important instability of antigen during both encapsulation and storage. Therefore, optimized procedures conditions require to be used to maintain the integrity of protein structure under several stress factors in formulation process. In this review article, the properties of PLGA particles, their preparation techniques and strategies for improvement of protein stability during encapsulation into PLGA, release from particle and storage as well as stabilization approaches were summarized. © 2018 Wiley Periodicals, Inc. J. Biomed. Mater. Res. Part A: 106A: 2540–2551, 2018

Item Type: Article
Uncontrolled Keywords: PLGA, Optimization, Formulation, Protein/peptide antigens
Subjects: R Medicine > RA Public aspects of medicine
R Medicine > RZ Other systems of medicine
Depositing User: Unnamed user with email eprints@gmu.ac.ir
Date Deposited: 06 Oct 2018 06:08
Last Modified: 06 Oct 2018 06:08
URI: http://eprints.gmu.ac.ir/id/eprint/460

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