Antibody-drug conjugates (ADCs) for cancer therapy: Strategies, challenges, and successes

Abdollahpour-Alitappeh, Meghdad and Lotfinia, Majid and Gharibi, Tohid and Mardaneh, Jalal and Farhadihosseinabadi, Behrouz and Larki, Pegah and Faghfourian, Babak and Sepehr, Koushan Sineh and Abbaszadeh-Goudarzi, Kazem and Abbaszadeh-Goudarzi, Ghasem and Johari, Behrooz and Zali, Mohammad Reza and Bagheri, Nader (2018) Antibody-drug conjugates (ADCs) for cancer therapy: Strategies, challenges, and successes. Journal of Cellular Physiology, 234 (5). pp. 5628-5642. ISSN 00219541

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Official URL: http://doi.org/10.1002/jcp.27419

Abstract

Targeted delivery of therapeutic molecules into cancer cells is considered as a promising strategy to tackle cancer. Antibody-drug conjugates (ADCs), in which a monoclonal antibody (mAb) is conjugated to biologically active drugs through chemical linkers, have emerged as a promising class of anticancer treatment agents, being one of the fastest growing fields in cancer therapy. The failure of early ADCs led researchers to explore strategies to develop more effective and improved ADCs with lower levels of unconjugated mAbs and more-stable linkers between the drug and the antibody, which show improved pharmacokinetic properties, therapeutic indexes, and safety profiles. Such improvements resulted in the US Food and Drug Administration approvals of brentuximab vedotin, trastuzumab emtansine, and, more recently, inotuzumab ozogamicin. In addition, recent clinical outcomes have sparked additional interest, which leads to the dramatically increased number of ADCs in clinical development. The present review explores ADCs, their main characteristics, and new research developments, as well as discusses strategies for the selection of the most appropriate target antigens, mAbs, cytotoxic drugs, linkers, and conjugation chemistries.

Item Type: Article
Subjects: R Medicine > RZ Other systems of medicine
Depositing User: Unnamed user with email eprints@gmu.ac.ir
Date Deposited: 22 Sep 2019 05:23
Last Modified: 22 Sep 2019 05:23
URI: http://eprints.gmu.ac.ir/id/eprint/579

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