The analysis of correlation between IL-1B gene expression and genotyping in multiple sclerosis patients

Heidary, Masoumeh and Rakhshi, Nahid and Kakhki, Majid Pahlevan and Behmanesh, Mehrdad and Sanati, Mohammad Hossein and Sanadgol, Nima and Kamaladini, Hossein and Nikravesh, Abbas (2014) The analysis of correlation between IL-1B gene expression and genotyping in multiple sclerosis patients. Journal of the Neurological Sciences, 343 (1–2). 41 - 45.

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Abstract

Abstract IL-1B is released by monocytes, astrocytes and brain endothelial cells and seems to be involved in inflammatory reactions of the central nervous system (CNS) in multiple sclerosis (MS). This study aims to evaluate the expression level of IL-1B mRNA in peripheral blood mononuclear cells (PBMCs), genotype the rs16944 {SNP} and find out the role of this {SNP} on the expression level of IL-1B in {MS} patients. We found that the expression level of IL-1B in {MS} patients increased 3.336 times more than controls in {PBMCs} but the rs16944 {SNP} in the promoter region of IL-1B did not affect the expression level of this gene and there was not association of this {SNP} with {MS} in the examined population. Also, our data did not reveal any correlation between normalized expressions of IL-1B gene with age of participants, age of onset, and disease duration.

Item Type: Article
Uncontrolled Keywords: Cytokines
Subjects: R Medicine > R Medicine (General)
R Medicine > RZ Other systems of medicine
Depositing User: Unnamed user with email eprints@gmu.ac.ir
Date Deposited: 04 Mar 2017 05:53
Last Modified: 04 Mar 2017 05:53
URI: http://eprints.gmu.ac.ir/id/eprint/86

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